Sickboy follows 29-year-old Jeremie Saunders as he lives openly with Cystic Fibrosis and devotes his life to removing the stigma attached to chronic illness and disease. He demonstrates that laughing about the absurdity of CF can take away its power. The film traces the efforts by Jeremie and his best friends, Brian and Taylor, to create an internet podcast that seeks to change the way people view serious illness like brain cancer, schizophrenia, and epilepsy.